Repeated Administration And Drug Cumulation

If a drug is excreted slowly, its administration may build up a sufficiently high concentration in the body to produce toxicity. e.g. digitalis, emetine. To avoid cumulation.

a) One must know if a drug is eliminated slowly or rapidly,

b) Stop the drug administration at the appearance of the first warning symptoms c) Carefully select the form in which the drug is to be administered.
d) Check liver and kidney function before and during drug administration, as even an otherwise non-cumulative drug would produce cumulation in the presence of hepatic and renal damage.