Indomethacin

Indomethacin is slightly more toxic but in certain circumstances more effective than aspirin. Indomethacin is well absorbed after oral administration and highly bound to plasma proteins. Metabolism occurs in the liver and unchanged drug and inactive metabolites are excreted in bile and urine.

Clinical Uses: treatment of patent ductus arteriosus, acute gouty arthritis and ankylosing spondylitis, pericarditis and pleurisy.

Adverse Effects: The gastrointestinal effects may include abdominal pain, diarrhea, gastrointestinal hemorrhage, and pancreatitis. CNS effects include be associated with dizziness, confusion, and depression. Serious hematologic reactions’ including thrombocytopenia and aplastic anemia has been reported.