Toxic epidermal necrolysis (TEN)

Toxic epidermal necrolysis (TEN) is a potentially life-threatening disorder that produces widespread blistering and peeling of the skin. TEN is most commonly induced by a drug (for example, an antibiotic or other medication), but other triggers occasionally cause TEN (triggers like an infection or a malignancy). With severe TEN, occasionally the barrier and containment properties of the skin are dangerously compromised and the patient’s condition resembles that of a burn patient.

Early treatment involves identifying the trigger or causative drug or agent and removing or keeping the compound away from the patient. Hospitalization is recommended; for severe TEN, a burn unit is suggested. Other treatments may include the following:

• IV fluids, carefully monitor
• Protective bandages especially where the skin has peeled off
• Ointments
• Pain control
• Antibiotics or antivirals
• IV immunoglobulin G
• Anticonvulsants