Protien Synthesis Inhibitors

Bacteria have two ribosomal subunits; 30S and 50S. The 30S subunit binds mRNA in initiation and holds growing peptide chain. The 50S subunit accepts / translocates charged tRNAs. Protien synthesis inhibitors are divided into two groups: bacteriostatic and bactericidal. Chloramphenicol, macrolides, clindamycin (Lincosamides), and tetracyclines are bacteriostatic whereas aminoglycosides are bactericidal.