Nonnucleoside Reverse Transcriptase Inhibitors (NNRTI)

Nonnucleoside reverse transcriptase inhibitors are a group of structurally diverse antiretroviral agents that have a similar mechanism of action. Nonnucleoside reverse transcriptase inhibitors interfere with the function of reverse transcriptase by binding directly to the enzyme in a noncompetitive fashion. The NNRTIs do not depend on intracellular conversion to an active metabolite.There are 2 nonnucleoside reverse transcriptase inhibitors commercially available.