e.g cromolyn sodium
Mechanism of action
Stabilize the mast cells so that release of histamine and other mediators is inhibited through alteration in the function of delayed chloride channel in cell membrane. It has no role once mediator is released and is used for casual prophylaxis.
Clinical uses
- Exercise and antigen induced asthma
- Occupational asthma
Side effects
Poorly absorbed so minimal side effect
Throat irritation, cough, dryness of mouth, chest tightness and wheezing
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