Kanamycin, Neomycin, Paromomycin

These drugs are closely related is also a member of this group. All have similar properties. Neomycin and kanamycin are too toxic for parenteral use and are now limited to topical and oral use. Neomycin is given orally in preparation for elective bowel surgery. In hepatic coma, the coliform flora can be suppressed for prolonged periods by giving 1 g every 6-8 hours together with reduced protein intake, thus reducing ammonia intoxication. Paromomycin has been effective in intestinal amebiasis.