As was written, each type of radiation interacts with matter in a different way. For example charged particles with high energies can directly ionize atoms. Alpha particles are fairly massive and carry a double positive charge, so they tend to travel only a short distance and do not penetrate very far into tissue if at all. However alpha particles will deposit their energy over a smaller volume (possibly only a few cells if they enter a body) and cause more damage to those few cells.
Beta particles (electrons) are much smaller than alpha particles. They carry a single negative charge. They are more penetrating than alpha particles. They can travel several meters but deposit less energy at any one point along their paths than alpha particles. This means beta particles tend to damage more cells, but with lesser damage to each. On the other hand electrically neutral particles interacts only indirectly, but can also transfer some or all of their energies to the matter.
It would certainly simplify matters if biological effects of radiation were directly proportional to the absorbed dose. Unfortunately, biological effects depend also on the way in which the absorbed dose is distributed along the path of the radiation. Studies have shown that alpha and neutron radiation cause greater biological damage for a given energy deposition per kg of tissue than gamma radiation does. It was discovered, biological effects of any radiation increases with the linear energy transfer (LET). In short, the biological damage from high-LET radiation (alpha particles, protons or neutrons) is much greater than that from low-LET radiation (gamma rays). This is because the living tissue can more easily repair damage from radiation that is spread over a large area than that which is concentrated in a small area. Of course, at very high levels of exposure gamma rays can still cause a great deal of damage to tissues.
Because more biological damage is caused for the same physical dose (i.e., the same energy deposited per unit mass of tissue), one gray of alpha or neutron radiation is more harmful than one gray of gamma radiation. This fact that radiations of different types (and energies) give different biological effects for the same absorbed dose is described in terms of factors known as the relative biological effectiveness (RBE) and the radiation weighting factor (wR).
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