Cell Membrane Function Inhibitors

Antimirobials such as polymyxins acting on gram negative bacteria and affects the functional integrity of the cytoplasmic membrane, macromolecules and ions escape from the cell and cell damage and death occurs. The two most well known agents are poymyxin B and colistin. Polymyxins are effective against Gram-negative bacteria, particularly pseudomonas species. The major adverse effects are nephrotoxicity dizziness, alterd sensation and neuromuscular paralysis.