Category: 07. Drugs For Diseases Of Blood, Inflammation And Gout

Very small amount are execrated in stool by exfoliation of intestinal mucosal cells and trace amounts are execrated in bile, urine and sweat with total daily excretion not more than 1mg/day.

Iron is absorbed in duodenum and proximal jejunum. A normal individual with out iron deficiency absorbs 5-10 % of daily intakes. Absorption is increased in states with increased requirements or deficiencies (low iron stores, pregnancy, menstruation, growing children, and blood loss) and/or dietary factors such as heme-iron (from meat, etc), HCl and vitamin C. Absorption…

Daily requirement of Iron – Male 10mg – Female 15 mg Increases in growing children, pregnant and lactating women Sources Dietary – mostly in the organic form from meat, cereals, etc. Body composition of Iron Total content of Iron in the body is about 4000mg in an adult male, of which about 2/3 – 2500…

Nutritional deficiency Low intake of iron containing foods, reduced absorption as a result of mucosal damage, co- administration of drugs that chelate iron e.g. antacids and after gastrectomy iron deficiency will take place. Chronic blood loss Chronic nose bleeding, Menorrhagia, Occult GI bleeding, Worm infestation and Ulers, e.g. PUD.

Iron forms the nucleus of the iron porphyrin heme ring, which together with globin chains forms hemoglobin that reversibly binds oxygen and provides the critical mechanism for oxygen delivery from lungs to other tissues. In the absence of adequate iron, small erythrocytes with insufficient hemoglobin are formed resulting in microcytic hypochromic anemia.

Hematopoiesis, the production of circulating erythrocytes, platelets and leukocytes from undifferentiated stem cells, is a remarkable process that produces over 200 billion new cells per day in the normal person and even greater number of blood cells in people with conditions that causes loss or destruction of blood cells. The hemopoietic machinery resides primarily in…