NSAIDS in Gout

Indomethacin and other NSAIDs inhibit urate crystal phagocytosis. Indomethacin may be used as initial treatment of gout or as an alternative drug when colchicine is unsuccessful or causes too much discomfort. Indomethacin is the agent most often used today to treat acute gout. All other NSAIDs except aspirin can be used to treat acute gouty episodes.