Rofecoxib

Rofecoxib is a highly selective and specific COX-2 inhibitor. It inhibits prostaglandin synthesis via inhibiting cyclooxygenase- 2. It is about 90% bound to plasma proteins. The main adverse effects are nausea, dyspepsia, epigastric discomfort, heart burn, diarrhea, fluid retention etc. It is mainly useful in osteoarthritis, acute pain like dental pain & primary dysmenorrhoea.