Diclofenac

Diclofenac is a potent cyclooxygenase inhibitor with antiinflammatory, analgesic, and antipyretic properties. The drug is rapidly absorbed following oral administration and has a half-life of 1-2 hours. It accumulates in the synovial fluid. The potency of diclofenac as a cyclooxygenase inhibitor is greater than that of naproxen. The drug is recommended for chronic inflammatory conditions such as rheumatoid arthritis and osteoarthritis and for the treatment of acute musculoskeletal pain. Adverse effects include gastrointestinal distress, occult gastrointestinal bleeding, and gastric ulceration.