Ibuprofen

Ibuprofen is extensively metabolized in the liver, and little is excreted unchanged. Gastrointestinal irritation and bleeding occur, though less frequently than with aspirin. In addition to the gastrointestinal symptoms, rash, pruritus, tinnitus, dizziness, headache, and fluid retention have been reported. Rare hematologic effects include agranulocytosis and aplastic anemia. Effects on the kidney include acute renal failure, interstitial nephritis, and nephrotic syndrome, occurring very rarely.