The newer NSAIDs inhibit of biosynthesis of prostaglandins. In addition they inhibit chemotaxis, down-regulate interleukin-1 production, and interfere with calcium-mediated intracellular events. These drugs are reversible inhibitors of cyclooxygenase.
Most of these drugs are well absorbed. Most of the NSAIDs are highly metabolized, some by phase I and phase II mechanisms and others by direct glucuronidation (phase II) alone. While renal excretion is the most important route, all undergo varying degrees of biliary excretion and reabsorption (enterohepatic circulation). All of the NSAIDs are highly protein-bound, usually to albumin.
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