Streptomycin

Most tubercle bacilli are inhibited by streptomycin. Streptomycin penetrates into cells poorly, and thus it is active mainly against extracellular tubercle bacilli. Streptomycin crosses the blood- brain barrier and achieves therapeutic concentrations with inflamed meninges. It is employed principally in individuals with severe, possibly life-threatening forms of tuberculosis (meningitis and disseminated disease), and in treatment of infections resistant to other drugs.