Cycloserine

Cycloserine inhibits many gram-positive and gram-negative organisms, but it is used almost exclusively to treat tuberculosis caused by strains of M tuberculosis resistant to first-line agents. It is widely distributed in tissues. Most of the drug is excreted in active form into the urine. Cycloserine causes serious dose-related central nervous system toxicity with headaches, tremors, acute psychosis, and convulsions.