Ergometrine

It is one of the ergot alkaloids with the ability to cause contraction of the uterine smooth muscle.

It causes sustained uterine contraction. It is completely absorbed after subcutaneous and intravenous administration. It is metabolized in the liver and eliminated in the urine .Liver damage enhances the toxicity of ergot alkaloid.

Use: after delivery of placenta if bleeding is severe (Prevent postpartum bleeding) Adverse effect: Nausa, vomiting but serious toxic effects are rare.