They induce labor at anytime during pregnancy but most effective at the third trimester. In female reproductive system prostaglandin E & F are found in ovaries, endometrium and menstrual fluid which is responsible for initiating and maintaining normal birth process. PGF, PGF2ά, PGE stimulate both the tone and amplitude of the uterine contraction.
Adverse reaction: nausa, vomiting, headache, diarrhea, fever, etc.
PGs should be used cautiously in the presence of hypertension, angina, and diabetes. They are contraindicated in the presence of cardiac, renal, pulmonary or hepatic disease.
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