Amantadine, an antiviral agent, was by chance found to have antiparkinsonism properties. Its mode of action in parkinsonism is unclear, but it may potentiate dopaminergic function by influencing the synthesis, release, or reuptake of dopamine.
Acetylcholine Blocking Drugs (Benztropine, Trihexyphenidyl)
A number of centrally acting antimuscarinic preparations are available that differ in their potency and in their efficacy in different patients. Treatment is started with a low dose of one of the drugs in this category, the level of medication gradually being increased until benefit occurs or adverse effects limit further increments. Antimuscarinic drugs may improve the tremor and rigidity of Parkinsonism but have little effect on bradykinesia.
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