Locally active agents help to heal gastric and duodenal ulcers by forming a protective barrier between the ulcers and gastric acid, pepsin, and bile salts.
- They do not alter the secretion of gastric acid. These drugs include sucralfate and colloid bismuth compounds. (e.g. tripotassium, dicitratobismuthate)
- Colloidal bismuth compounds additionally exert bactericidal action against H.pylori.
Other drugs that can to eradicate H.pylori such as amoxicillin, metronidazole, clarithromycin and tetracycline are included in the anti-ulcer treatment regimens.
- Protaglandins have both antisecretory and mucosal protective effects.
Example: Misoprostol– used for prevention of NSAID – induced ulcer.
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