Organic nitrates e.g. nitro-glycerine, isosorbide dinitrate, etc. Beta adrenergic blocking agents e.g. propranolol, atenolol, etc. Calcium channel blocking agents e.g. verapamil, nifedipine, etc. Miscellaneous drugs e.g. aspirin, heparin, dipyridamole.
- Organic nitrates: organic nitrates are potent vasodilators and successfully used in therapy of angina pectoris for over 100 years.
The effects of nitrates are mediated through the direct relaxant action on smooth muscles. Nitrates are believed to act by mimicking the vasodilator action of endothelium derived relaxing factor (EDRF) identified as nitric oxide. Vasodilating organic nitrates are reduced to organic nitrites, which is then converted to nitric oxide.
The action of nitrates begins after 2-3 minutes when chewed or held under tongue and action lasts for 2 hours. The onset of action and duration of action differs for different nitrates and varying pharmaceutical preparations.
Adverse effects include flushing, weakness, dizziness, tachycardia, palpitation, vertigo, sweating, syncope localized burning with sublingual preparation and contact dermatitis with ointment.
Therapeutic uses: prophylaxis and treatment of angina pectoris, post myocardial infarction, coronary insufficiency, acute LVF (left ventricle failure)
- Adrenergic blocking agents
Exercise and emotional excitement induce angina in susceptible subject by the increase in heart rate, blood pressure and myocardial contractility through increased sympathetic activity.
Beta receptor blocking agents prevent angina by blocking all these effects. In most patients the net effect is a beneficial reduction in cardiac workload and myocardial oxygen consumption e.g. atenolol, propranolol metoprolol, labetolol.
Adverse effects: Lethargy, fatigue, rash, cold hands and feet, nausea, breathlessness, nightmares and bronchospasm. Selective beta blockers have relatively lesser adverse effects.
Therapeutic uses other than angina include hypertension, Cardiac arrhythmias, post myocardial infarction and pheochromocytoma.
- Calcium channel blockers: calcium is necessary for the excitation contraction coupling in both the cardiac and smooth muscles. Calcium channel blockers appear to involve their interference with the calcium entry into the myocardial and vascular smooth muscle, thus decreasing the availability of the intracellular calcium e.g. nifedipine, felodipine, verapamil and diltiazem.
Other therapeutic uses: hypertension, acute coronary insufficiency, tachycardia,
Adverse effects: flushing nausea/vomiting, headache, Ankle swelling, dizziness, constipation, etc.
- Miscellaneous drugs,e.g. Acetylsalicylic acid
Acetylsalicylic acid (aspirin) at low doses given intermittently decreases the synthesis of thromboxne A2 without drastically reducing prostacylin synthesis. Thus, at the doses of 75 mg per day it can produce antiplatelet activity and reduce the risk of myocardial infarction in anginal patients.
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