SYNTHETIC ATROPINE DERIVATIVES

There are a number of synthetic atropine derivatives, which are used in the treatment of various conditions, their actions are similar to that of atropine but have fewer side effects. These groups of drugs include

1. Mydriatic atropine substitutes, this group of drugs have shorter duration of action than atropine and are used locally in the eye; drugs included: Homatropine, Eucatropine etc.
2. Antiseccretory antispasmodic atropine substitutes:

– Effective more localized to the Gl. Drugs include: propantheline and hyoscine

• Antiparkinsonian atropine substitute: – drugs like Benztropine, Trihexyphenidyl
• Atropine substitutes which decrease urinary bladder activity like oxybutynin
• Atropine substitutes used in bronchial asthma drugs like ipratropium